A clinico-pathological observation of one case of nonabsorbable sutures in the superior right eyelid was reported in a 79-year-old patient. The main clinical finding was a painful reddish eyelid. Surgical excision was performed. Histopathological analysis found a non-granulomatous chronic inflammatory reaction surrounding suture fragments. Uncommon in eyelids, such an inflammatory reaction against sutures attests the likely intolerance to the suture material.