No difference in survival between sporadic, familial and hereditary prostate cancer

Br J Urol. 1998 Oct;82(4):564-7. doi: 10.1046/j.1464-410x.1998.00801.x.

Abstract

Objective: To estimate the survival of men with familial prostate cancer and compare them with prostate cancer cases unselected for family history.

Patients and methods: The overall and prostate cancer-specific survival was calculated in two large (249 and 304 men, respectively) population-based cohorts of men with familial prostate cancer. The tumour grade at diagnosis was also obtained in one of the cohorts.

Results: There were no significant differences in either overall or prostate cancer-specific survival between familial and sporadic cases. The spectrum of tumour grades at diagnosis in familial cases did not differ from that in a population with prostate cancer unselected for family history.

Conclusion: No differences in treatment between men with or without a positive family history of prostate cancer are justified, based on the result from this study.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cohort Studies
  • Humans
  • Male
  • Neoplastic Syndromes, Hereditary / genetics
  • Neoplastic Syndromes, Hereditary / mortality*
  • Pedigree
  • Prognosis
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / mortality*
  • Survival Analysis
  • Survival Rate
  • Sweden / epidemiology