Abstract
In this report, we have identified, sequenced, and characterized the expression pattern of a novel human gene, mammaglobin B. Mammaglobin B (MGB2) is highly homologous to mammaglobin (MGB1), a previously characterized human gene whose expression is limited to the mammary epithelium and frequently up-regulated in human breast cancer cells. Based upon amino acid sequence similarities, both mammaglobin and mammaglobin B may be considered members of a larger, mammalian multigene family that includes rabbit uteroglobin, human Clara Cell 10-kDa protein (CC10), and the multimeric rat prostatein protein. Together with the human CC10 gene, mammaglobin and mammaglobin B are closely linked on human chromosome 11q13. However, despite their primary sequence similarity and close chromosomal proximity, the expression of mammaglobin and mammaglobin B is nonconcordant in both nonmalignant and neoplastic tissue.
Copyright 1998 Academic Press.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Base Sequence
-
Blotting, Northern
-
Breast / metabolism
-
Breast Neoplasms / metabolism
-
Chromosomes, Human, Pair 11 / genetics
-
Female
-
Humans
-
In Situ Hybridization, Fluorescence
-
Mammaglobin A
-
Mammaglobin B
-
Molecular Sequence Data
-
Myelin Proteins
-
Neoplasm Proteins / chemistry
-
Neoplasm Proteins / genetics*
-
Neoplasm Proteins / metabolism
-
Polymerase Chain Reaction
-
Proteins / genetics
-
Proteolipids
-
RNA, Messenger / genetics
-
RNA, Messenger / metabolism
-
Salivary Glands / metabolism
-
Secretoglobins
-
Uterine Neoplasms / metabolism
-
Uteroglobin / chemistry
-
Uteroglobin / genetics*
-
Uteroglobin / metabolism
-
Uterus / metabolism
Substances
-
Mammaglobin A
-
Mammaglobin B
-
Myelin Proteins
-
Neoplasm Proteins
-
Proteins
-
Proteolipids
-
RNA, Messenger
-
SCGB1A1 protein, human
-
SCGB2A1 protein, human
-
SCGB2A2 protein, human
-
Scgb1a1 protein, rat
-
Secretoglobins
-
Uteroglobin