Abstract
Thirteen hepatitis B surface antigen-positive Chinese patients who received hepatitis B surface antibody-positive marrow (hepatitis B core antibody-positive or -negative: 6 and 7, respectively) via allogeneic bone marrow transplantation (BMT) were studied. After BMT, 4 recipients had serologic clearance of hepatitis B surface antigen from hepatitis B core antibody-positive marrow, but none of the recipients of hepatitis B core antibody-negative marrow had serologic clearance (P=.02). There was no significant difference in the donors' hepatitis B surface antibody titer before BMT for patients with or without serologic clearance of hepatitis B surface antigen (2255.2+/-4244.0 vs. 854.2+/-2306.7 mIU/mL; P=not significant). Adoptive immunity clearance of hepatitis B surface antigen was favored by hepatitis B core antibody positive-donor marrow and was not related to donor pre-BMT hepatitis B surface antibody titer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Bone Marrow / immunology
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Bone Marrow Transplantation / adverse effects
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Bone Marrow Transplantation / immunology*
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Child
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China / ethnology
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DNA, Viral / blood
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Female
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Hepatitis B / immunology
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Hepatitis B / transmission*
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Hepatitis B Antibodies / blood*
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Hepatitis B Core Antigens / analysis
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Hepatitis B Core Antigens / immunology*
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Hepatitis B Surface Antigens / analysis
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Hepatitis B Surface Antigens / blood*
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Hepatitis B Surface Antigens / immunology*
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Hepatitis B e Antigens / analysis
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Hepatitis B virus / isolation & purification
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Hong Kong
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Humans
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Liver Diseases / etiology
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Living Donors*
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Male
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Middle Aged
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Postoperative Complications
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Retrospective Studies
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Reverse Transcriptase Polymerase Chain Reaction
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Transplantation, Homologous
Substances
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DNA, Viral
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Hepatitis B Antibodies
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Hepatitis B Core Antigens
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Hepatitis B Surface Antigens
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Hepatitis B e Antigens