Prognostic value of JC virus load in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy

Y Taoufik; J Gasnault; A Karaterki; M Pierre Ferey; E Marchadier; C Goujard; A Lannuzel; J F Delfraissy; E Dussaix

doi:10.1086/314496

Prognostic value of JC virus load in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy

J Infect Dis. 1998 Dec;178(6):1816-20. doi: 10.1086/314496.

Authors

Y Taoufik¹, J Gasnault, A Karaterki, M Pierre Ferey, E Marchadier, C Goujard, A Lannuzel, J F Delfraissy, E Dussaix

Affiliation

¹ Department of Microbiology, Paul Brousse Hosptial, Cedex, France. [email protected]

PMID: 9815242
DOI: 10.1086/314496

Abstract

JC virus (JCV) load was determined by using quantitative polymerase chain reaction in cerebrospinal fluid (CSF) of 12 patients with AIDS-associated progressive multifocal leukoencephalopathy (PML) and compared with clinical outcome. JCV loads varied widely (3-7 log10 JCV equivalents/mL of CSF) and were apparently not related to absolute CD4 cell counts or CSF and plasma human immunodeficiency virus type 1 loads. A significant correlation was observed between JCV load and survival time (Spearman's rank correlation, -0.83; P<. 01). Moreover, CSF JCV load decreased and then became undetectable in 1 PML patient receiving cidofovir treatment, and this was associated with clinical improvement. These results show that CSF JCV load may be useful as a prognostic parameter and in monitoring the effectiveness of anti-JCV therapies in PML patients.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

AIDS Dementia Complex / cerebrospinal fluid*
AIDS Dementia Complex / physiopathology
AIDS Dementia Complex / virology*
AIDS-Related Opportunistic Infections / cerebrospinal fluid
AIDS-Related Opportunistic Infections / drug therapy
Antiviral Agents / therapeutic use
CD4 Lymphocyte Count
Cidofovir
Cytosine / analogs & derivatives
Cytosine / therapeutic use
DNA Primers
DNA Probes
DNA, Viral / cerebrospinal fluid
Female
HIV-1 / growth & development
HIV-1 / isolation & purification*
Humans
JC Virus / isolation & purification*
Male
Organophosphonates*
Organophosphorus Compounds / therapeutic use
Papillomavirus Infections / cerebrospinal fluid*
Papillomavirus Infections / drug therapy
Papillomavirus Infections / etiology
Polymerase Chain Reaction
Predictive Value of Tests
Prognosis
Statistics, Nonparametric
Tumor Virus Infections / cerebrospinal fluid*
Tumor Virus Infections / drug therapy
Tumor Virus Infections / etiology
Viral Load

Substances

Antiviral Agents
DNA Primers
DNA Probes
DNA, Viral
Organophosphonates
Organophosphorus Compounds
Cytosine
Cidofovir