Abstract
We assessed the effects of intracoronary administration of substance P, LNMMA, L-arginine, and nitroglycerin in patients with normal coronary angiograms and in patients with coronary artery disease. LNMMA constricted (p <0.01) and both substance P and nitroglycerin dilated normal and diseased proximal and distal segments and stenoses (p <0.01). L-Arginine reversed the effect of LNMMA in all segments and caused greater dilation of the diseased arteries, including stenoses (p <0.05), indicating that there is a relative deficiency of L-arginine in diseased coronary arteries.
MeSH terms
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Aged
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Angina Pectoris / physiopathology*
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Arginine / pharmacology*
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Coronary Angiography
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Coronary Artery Disease / physiopathology*
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Coronary Vessels / physiopathology*
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Endothelium, Vascular / physiopathology*
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Enzyme Inhibitors / pharmacology
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Female
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Humans
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Male
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Middle Aged
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Nitric Oxide Synthase / antagonists & inhibitors
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Nitric Oxide Synthase / metabolism*
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Nitroglycerin / pharmacology
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Substance P / pharmacology
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Vasoconstriction / drug effects
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Vasoconstriction / physiology*
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omega-N-Methylarginine / pharmacology
Substances
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Enzyme Inhibitors
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omega-N-Methylarginine
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Substance P
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Arginine
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Nitric Oxide Synthase
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Nitroglycerin