Abstract
The widespread expression of CD40 in normal epithelial cells and carcinoma cells suggests that this receptor has important, additional influences beyond that of regulating immune responses. Here, Lawrence Young and colleagues discuss the effect of CD40 ligation on epithelial cells and consider the role of this pathway in the pathogenesis and treatment of carcinomas.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Antigens, Viral
-
CD40 Antigens / physiology*
-
Carcinoma / immunology
-
Epithelial Cells / immunology*
-
Herpesvirus 4, Human / immunology
-
Humans
-
Immunohistochemistry
-
Membrane Proteins / immunology
-
Mice
-
Mice, Knockout
-
Molecular Mimicry / immunology
-
Signal Transduction
-
Viral Matrix Proteins / immunology
Substances
-
Antigens, Viral
-
CD40 Antigens
-
EBV-associated membrane antigen, Epstein-Barr virus
-
Membrane Proteins
-
Viral Matrix Proteins