Abstract
Unlike mammalian species, several cold-blooded species have been shown to possess multiple forms of complement components. The multiple forms of C3 characterized in several fish species can bind with different specificities to various complement-activating surfaces. Here, Oriol Sunyer, Ioannis Zarkadis and John Lambris explore the possible advantages conferred by having multiple forms of individual complement proteins in a single organism.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Biological Evolution
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Complement C3 / immunology
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Complement C3 / metabolism
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Complement System Proteins / chemistry*
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Complement System Proteins / classification*
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Complement System Proteins / immunology
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Electrophoresis, Polyacrylamide Gel
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Erythrocytes / metabolism
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Fishes / immunology
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Genetic Variation / immunology*
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Immunity, Innate*
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Phylogeny
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Rabbits
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Sheep
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Zymosan / immunology
Substances
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Complement C3
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Complement System Proteins
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Zymosan