Repression by the Mad(Mxi1)-Sin3 complex

Bioessays. 1998 Oct;20(10):808-18. doi: 10.1002/(SICI)1521-1878(199810)20:10<808::AID-BIES6>3.0.CO;2-U.

Abstract

The functions of Myc in transformation and transactivation are countered by the suppressive actions of the Mad(Mxi1) family. Mad(Mxi1) proteins not only compete with Myc for dimerization to Max and binding to Myc/Max consensus sites but also recruit powerful repressors of gene expression. A prediction of the yin-yang relationship between Myc and Mad(Mxi1) families would be that the latter constitutes a new class of tumor suppressors. Here, we review the current literature on the Mad(Mxi1) family, with particular attention paid to the molecular mechanisms by which these proteins antagonize the actions of Myc in normal and neoplastic cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Basic Helix-Loop-Helix Transcription Factors
  • Basic-Leucine Zipper Transcription Factors
  • Binding Sites
  • Binding, Competitive
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / metabolism
  • Chromatin / genetics
  • Consensus Sequence
  • DNA-Binding Proteins / metabolism*
  • DNA-Binding Proteins / physiology*
  • Dimerization
  • Eukaryotic Cells / metabolism
  • Gene Expression Regulation* / physiology*
  • Gene Expression Regulation, Neoplastic
  • Genes, Tumor Suppressor
  • Histone Deacetylases
  • Mice
  • Mice, Knockout
  • Models, Genetic
  • Multigene Family
  • Neoplasms / genetics
  • Nuclear Proteins / physiology
  • Nuclear Receptor Co-Repressor 1
  • Proto-Oncogene Proteins c-myc / antagonists & inhibitors*
  • Repressor Proteins / physiology*
  • Saccharomyces cerevisiae Proteins*
  • Transcription Factors / physiology*
  • Transcriptional Activation / physiology*
  • Tumor Suppressor Proteins

Substances

  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Basic Helix-Loop-Helix Transcription Factors
  • Basic-Leucine Zipper Transcription Factors
  • Chromatin
  • DNA-Binding Proteins
  • MXD1 protein, human
  • MXI1 protein, human
  • Mad protein, mouse
  • Mxi1 protein, mouse
  • Myc associated factor X
  • NCOR1 protein, human
  • Ncor1 protein, mouse
  • Nuclear Proteins
  • Nuclear Receptor Co-Repressor 1
  • Proto-Oncogene Proteins c-myc
  • Repressor Proteins
  • SIN3 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • Tumor Suppressor Proteins
  • Max protein, mouse
  • Histone Deacetylases