Abstract
PPARgamma is a member of the peroxisome proliferator activated receptors (PPAR) subfamily of nuclear receptors. So far two PPARgamma isoforms, PPARgamma1 and PPARgamma2, were known in mammals. We describe the structure of a novel human PPARgamma subtype, PPARgamma3. The PPARgamma3 mRNA is transcribed from a novel promoter localized 5' of exon A2. PPARgamma3 mRNA expression was restricted to adipose tissue and large intestine. Similar to human PPARgamma1 and -2, PPARy3 is activated by thiazolidinediones and prostaglandin J derivatives and binds with high affinity to a PPRE.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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5' Untranslated Regions / genetics
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Adipose Tissue
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Adult
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Animals
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Base Sequence
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Cell Line
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Dimerization
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Exons / genetics
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Humans
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Intestine, Large
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Molecular Sequence Data
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Promoter Regions, Genetic / genetics*
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Prostaglandins / pharmacology
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Protein Isoforms / genetics
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RNA, Messenger / analysis
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Receptors, Cytoplasmic and Nuclear / genetics*
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Receptors, Cytoplasmic and Nuclear / metabolism
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Receptors, Retinoic Acid / metabolism
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Response Elements / genetics*
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Retinoid X Receptors
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Rosiglitazone
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Thiazoles / pharmacology
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Thiazolidinediones*
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Transcription Factors / genetics*
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Transcription Factors / metabolism
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Transcriptional Activation
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Transfection
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Tumor Cells, Cultured
Substances
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5' Untranslated Regions
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Prostaglandins
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Protein Isoforms
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RNA, Messenger
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Receptors, Cytoplasmic and Nuclear
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Receptors, Retinoic Acid
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Retinoid X Receptors
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Thiazoles
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Thiazolidinediones
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Transcription Factors
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Rosiglitazone