Novel CDC25A phosphatase inhibitors from pyrolysis of 3-alpha-azido-B-homo-6-oxa-4-cholesten-7-one on silica gel

J Med Chem. 1998 Nov 19;41(24):4677-80. doi: 10.1021/jm980500r.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetates / chemical synthesis*
  • Acetates / chemistry
  • Acetates / pharmacology
  • Azides / chemistry*
  • Cholestenones / chemistry*
  • Crystallography, X-Ray
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Fluoresceins / metabolism
  • Gels
  • Indans / chemical synthesis*
  • Indans / chemistry
  • Indans / pharmacology
  • Molecular Conformation
  • Phosphorylation
  • Protein Tyrosine Phosphatases / antagonists & inhibitors*
  • Silica Gel
  • Silicon Dioxide*
  • Structure-Activity Relationship
  • cdc25 Phosphatases*

Substances

  • 3-azido-B-homo-6-oxa-4-cholesten-7-one
  • 5-(6-cyano-1-hexen-2-yl)-7a-methyl-1-(6-methylhept-2-yl)hexahydroindan-4-acetic acid
  • Acetates
  • Azides
  • Cholestenones
  • Enzyme Inhibitors
  • Fluoresceins
  • Gels
  • Indans
  • Silica Gel
  • Silicon Dioxide
  • Protein Tyrosine Phosphatases
  • cdc25 Phosphatases