Abstract
The EtOH extract of the leaves of Holarrhena curtisii yielded five new steroidal alkaloids: 17-epi-holacurtine (3), 17-epi-N-demethylholacurtine (4), holacurtinol (5), 3alpha-amino-14beta-hydroxypregnan-20-one (7), and 15alpha-hydroxyholamine (8), in addition to the known compounds, holacurtine (1), N-demethylholacurtine (2), and holamine (6). All eight compounds showed significant cytotoxic and leishmanicidal activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / isolation & purification
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Alkaloids / pharmacology*
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Animals
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antiprotozoal Agents / isolation & purification
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Antiprotozoal Agents / pharmacology*
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Drug Screening Assays, Antitumor
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HL-60 Cells
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Humans
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Leishmania donovani / drug effects*
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Leukemia P388 / drug therapy
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Magnetic Resonance Spectroscopy
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Mice
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Plants, Medicinal / chemistry*
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Steroids / isolation & purification
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Steroids / pharmacology*
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Antiprotozoal Agents
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Steroids