Abstract
We examined 22 clinical isolates of Staphylococcus epidermidis to analyze the association of alterations in GyrA and ParC with fluoroquinolone resistance. The simultaneous presence of GyrA and ParC alterations was associated with a high level of fluoroquinolone resistance in the clinical isolates of S. epidermidis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Quinolones
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Amino Acid Sequence
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Anti-Infective Agents / pharmacology*
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DNA Gyrase
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DNA Topoisomerase IV
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DNA Topoisomerases, Type II / genetics*
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DNA Topoisomerases, Type II / metabolism
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Drug Resistance, Microbial
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Mutation
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Polymerase Chain Reaction
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Staphylococcus epidermidis / drug effects*
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Staphylococcus epidermidis / enzymology
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Staphylococcus epidermidis / genetics
Substances
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4-Quinolones
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Anti-Infective Agents
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DNA Topoisomerase IV
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DNA Gyrase
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DNA Topoisomerases, Type II