Abstract
Vesicular traffic within the early secretory pathway is mediated by COPI- and COPII-coated vesicles. While COPII-coated vesicles appear to be involved exclusively in the export of secretory proteins and lipids from the endoplasmic reticulum (ER), COPI-coated vesicles seem to function in both anterograde and retrograde transport between the ER-Golgi intermediate compartment (IC) and the Golgi as well as in intra-Golgi transport. Here, we focus on (i) the mechanisms how these transport carriers are formed from a given donor membrane; and (ii) the possible mechanisms involved in sorting of proteins and lipids into such transport vesicles.
Copyright 1998 Academic Press.
MeSH terms
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Biological Transport / physiology*
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COP-Coated Vesicles
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Carrier Proteins / physiology*
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Cholesterol / metabolism
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Coated Vesicles / physiology
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Coatomer Protein
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Endoplasmic Reticulum, Rough / physiology*
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Eukaryotic Cells / physiology*
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Eukaryotic Cells / ultrastructure
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Fungal Proteins / physiology*
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GTP-Binding Proteins / physiology*
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GTPase-Activating Proteins
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Golgi Apparatus / physiology*
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Guanosine Triphosphate / physiology
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Macromolecular Substances
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Membrane Lipids / metabolism*
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Membrane Proteins / metabolism*
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Membrane Proteins / physiology*
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Models, Biological
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Monomeric GTP-Binding Proteins*
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Nuclear Pore Complex Proteins
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Phosphoproteins / physiology*
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Proteins / metabolism
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Saccharomyces cerevisiae Proteins*
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Sphingomyelins / metabolism
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Vesicular Transport Proteins
Substances
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Carrier Proteins
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Coatomer Protein
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Fungal Proteins
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GTPase-Activating Proteins
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Macromolecular Substances
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Membrane Lipids
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Membrane Proteins
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Nuclear Pore Complex Proteins
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Phosphoproteins
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Proteins
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SEC13 protein, S cerevisiae
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SEC23 protein, S cerevisiae
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SEC31 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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Sphingomyelins
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Vesicular Transport Proteins
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Guanosine Triphosphate
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Cholesterol
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GTP-Binding Proteins
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Monomeric GTP-Binding Proteins
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SAR1 protein, S cerevisiae