Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody

Springer Semin Immunopathol. 1998;20(1-2):247-59. doi: 10.1007/BF00832010.
No abstract available

Publication types

  • Review

MeSH terms

  • Aged
  • Animals
  • Antibodies, Monoclonal / pharmacology
  • Antibodies, Monoclonal / therapeutic use*
  • Antibody Specificity
  • Arthritis, Rheumatoid / immunology
  • Arthritis, Rheumatoid / physiopathology
  • Arthritis, Rheumatoid / therapy*
  • Cattle
  • Disease Models, Animal
  • Drug Therapy, Combination
  • Female
  • Humans
  • Interleukin-6 / physiology*
  • Macaca fascicularis
  • Mice
  • Mice, Inbred DBA
  • Rats
  • Receptors, Interleukin-6 / antagonists & inhibitors*
  • Recombinant Fusion Proteins / pharmacology
  • Recombinant Fusion Proteins / therapeutic use
  • Recombinant Proteins / immunology
  • Signal Transduction / drug effects*

Substances

  • Antibodies, Monoclonal
  • Interleukin-6
  • Receptors, Interleukin-6
  • Recombinant Fusion Proteins
  • Recombinant Proteins