Fibroblast growth factor (FGF)-9 immunoreactivity in senile plaques

S Nakamura; K Arima; S Haga; T Aizawa; Y Motoi; M Otsuka; A Ueki; K Ikeda

doi:10.1016/s0006-8993(98)01042-7

Fibroblast growth factor (FGF)-9 immunoreactivity in senile plaques

Brain Res. 1998 Dec 14;814(1-2):222-5. doi: 10.1016/s0006-8993(98)01042-7.

Authors

S Nakamura¹, K Arima, S Haga, T Aizawa, Y Motoi, M Otsuka, A Ueki, K Ikeda

Affiliation

¹ Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya, Tokyo 156-8585, Japan. [email protected]

PMID: 9838127
DOI: 10.1016/s0006-8993(98)01042-7

Abstract

We examined fibroblast growth factor (FGF)-9 immunoreactivity in human hippocampal sections of Alzheimer's disease (AD). FGF-9 immunoreactivity was observed in dystrophic neurites of senile plaques in AD and control cases, in addition to the hippocampal and cortical neurons. The amyloid core and neurofibrillary tangles lacked immunoreactivity. FGF-9 immunoreactive astrocytes were conspicuous in AD brains. FGF-9 may be involved in the neuropathology of AD.

Publication types

Clinical Trial
Controlled Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease / metabolism*
Fibroblast Growth Factor 9
Fibroblast Growth Factors*
Growth Substances / analysis*
Humans
Immunohistochemistry
Nerve Tissue Proteins / analysis*
Neurofibrillary Tangles / chemistry
Plaque, Amyloid / chemistry*

Substances

FGF9 protein, human
Fibroblast Growth Factor 9
Growth Substances
Nerve Tissue Proteins
Fibroblast Growth Factors