Human immunodeficiency virus type 1 subtypes differ in disease progression

J Infect Dis. 1999 Jan;179(1):68-73. doi: 10.1086/314557.

Abstract

At least 10 different genetic human immunodeficiency virus type 1 (HIV-1) subtypes (A-J) are responsible for the AIDS pandemic. Much of the understanding of HIV-1 disease progression derives from studies in the developed world where HIV infection is almost exclusively subtype B. This has led many to question whether the properties and consequences of HIV-1 infection can be generalized across subtypes that afflict the majority of infected persons in the developing world. From 1985 to 1997, a prospective study of registered female sex workers in Senegal tracked the introduction and spread of HIV-1 subtypes A, C, D, and G. In clinical follow-up, the AIDS-free survival curves differed by HIV-1 subtype. Women infected with a non-A subtype were 8 times more likely to develop AIDS than were those infected with subtype A (hazard ratio=8.23; P=. 009), the predominant subtype in the study. These data suggest that HIV-1 subtypes may differ in rates of progression to AIDS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acquired Immunodeficiency Syndrome / etiology
  • Acquired Immunodeficiency Syndrome / mortality
  • Base Sequence
  • DNA Primers / genetics
  • Female
  • HIV Infections / epidemiology
  • HIV Infections / transmission
  • HIV Infections / virology*
  • HIV Seropositivity
  • HIV-1 / classification*
  • HIV-1 / genetics
  • HIV-1 / pathogenicity
  • Humans
  • Phylogeny
  • Polymerase Chain Reaction
  • Prospective Studies
  • Senegal / epidemiology
  • Sex Work
  • Survival Rate
  • Time Factors

Substances

  • DNA Primers

Associated data

  • GENBANK/AF085284
  • GENBANK/AF085285
  • GENBANK/AF085286
  • GENBANK/AF085287
  • GENBANK/AF085288
  • GENBANK/AF085289
  • GENBANK/AF085290
  • GENBANK/AF085291
  • GENBANK/AF085292
  • GENBANK/AF085293
  • GENBANK/AF085294
  • GENBANK/AF085295
  • GENBANK/AF085296
  • GENBANK/AF085297
  • GENBANK/AF085298
  • GENBANK/AF085299
  • GENBANK/AF085300
  • GENBANK/AF085301
  • GENBANK/AF085302
  • GENBANK/AF085303
  • GENBANK/AF085304
  • GENBANK/AF085305
  • GENBANK/AF085306
  • GENBANK/AF085307
  • GENBANK/AF085308
  • GENBANK/AF085309
  • GENBANK/AF085310
  • GENBANK/AF085311
  • GENBANK/AF085312
  • GENBANK/AF085313