A HhaI/BstUI polymorphism in a novel gene at human chromosome 11p15.5

K Miura; H Masuzaki; T Ishimaru; N Niikawa; Y Jinno

doi:10.1007/s100380050092

A HhaI/BstUI polymorphism in a novel gene at human chromosome 11p15.5

J Hum Genet. 1998;43(4):283-4. doi: 10.1007/s100380050092.

Authors

K Miura¹, H Masuzaki, T Ishimaru, N Niikawa, Y Jinno

Affiliation

¹ Department of Human Genetics, Nagasaki University School of Medicine, Japan.

PMID: 9852686
DOI: 10.1007/s100380050092

Abstract

We found a HhaI/BstUI polymorphism in the 3' untranslated region of a novel gene which was localized to 11p15.5. This region is one of prominent imprinting domains and contains multiple imprinted genes, such as H19, IGF2, KVLQT1, and p57KIP2, which suggests that regional factors might contribute to the imprinting. This polymorphism will be useful in the allelic analysis of expression and methylation of the novel gene.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Chromosomes, Human, Pair 11*
DNA Methylation
Deoxyribonucleases, Type II Site-Specific / metabolism*
Gene Frequency
Genomic Imprinting
Humans
Polymorphism, Genetic

Substances

CGCG-specific type II deoxyribonucleases
Deoxyribonucleases, Type II Site-Specific
GCGC-specific type II deoxyribonucleases