Abstract
Synthesis and biological evaluation of new 1,2,5-oxadiazole N-oxide derivatives with potential cytotoxic effects are described. From the series of compounds tested, compounds 2 and 6 proved to be very active, although non-selective.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Cell Hypoxia / drug effects
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Cricetinae
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Cricetulus
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Cyclic N-Oxides / chemical synthesis*
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Cyclic N-Oxides / chemistry
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Cyclic N-Oxides / pharmacology
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Drug Screening Assays, Antitumor
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Models, Molecular
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Oxadiazoles / chemical synthesis*
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Oxadiazoles / chemistry
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Oxadiazoles / pharmacology
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Tumor Cells, Cultured
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X-Ray Diffraction
Substances
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3-chloromethyl-4-phenyl-1,2,5-oxadiazole-2-oxide
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4-phenyl-1,2,5-oxadiazole-3-carboxaldehyde-2-oxide
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Antineoplastic Agents
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Cyclic N-Oxides
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Oxadiazoles