Any modality that alters joint homeostasis could have a potential negative effect on cartilage. During arthroscopic knee surgery, the temperature in the knee joint decreases significantly. The use of cryotherapy after this surgical procedure could maintain or increase these temperature variations. This prospective, randomized study evaluated the change in intra-articular knee temperature with the use of the Cryo/Cuff (Aircast Inc, Summit, New Jersey) in 30 patients after arthroscopic knee surgery. In 15 patients, a Cryo/Cuff with an automatic pump was applied immediately after surgery (group 1), and in the remaining 15 patients, only a wound dressing was applied (group 2). The mean intra-articular temperature at the beginning of the procedure was 34.8+/-1 degrees C for both groups. At the end of surgery, the temperature was 26.8+/-2.2 degrees C for group 1 and 27.5+/-2.2 degrees C for group 2. One hour after the end of the procedure, the mean temperature was 34+/-1.6 degrees for group 1 and 34.8+/-1.7 degrees C for group 2. These differences were not statistically significant. These results demonstrated that the use of the Cryo/Cuff does not alter temperature recovery in the knee, thereby excluding potential damage to the articular cartilage.