Abstract
The pathogenesis of asthma reflects, in part, the activity of T cell cytokines. Murine models support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma. Selective neutralization of IL-13, a cytokine related to IL-4 that also binds to the alpha chain of the IL-4 receptor, ameliorated the asthma phenotype, including airway hyperresponsiveness, eosinophil recruitment, and mucus overproduction. Administration of either IL-13 or IL-4 conferred an asthma-like phenotype to nonimmunized T cell-deficient mice by an IL-4 receptor alpha chain-dependent pathway. This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adoptive Transfer
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Allergens / immunology
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Animals
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Asthma / genetics
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Asthma / immunology*
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Asthma / pathology
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Asthma / physiopathology
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Bronchial Hyperreactivity
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Bronchoalveolar Lavage Fluid / cytology
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Chromosomes, Human, Pair 5
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Goblet Cells / pathology
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Humans
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Immunoglobulin Fc Fragments
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Interleukin-13 / antagonists & inhibitors
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Interleukin-13 / genetics
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Interleukin-13 / pharmacology
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Interleukin-13 / physiology*
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Interleukin-13 Receptor alpha1 Subunit
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Interleukin-4 / genetics
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Interleukin-4 / pharmacology
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Interleukin-4 / physiology*
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Mice
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Mice, Inbred BALB C
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Ovalbumin / immunology
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Phenotype
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Receptors, Interleukin / genetics
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Receptors, Interleukin / immunology
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Receptors, Interleukin / physiology
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Receptors, Interleukin-13
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Receptors, Interleukin-4 / genetics
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Receptors, Interleukin-4 / physiology
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Recombinant Fusion Proteins / pharmacology
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Th2 Cells / immunology
Substances
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Allergens
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IL13RA1 protein, human
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Il13ra1 protein, mouse
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Immunoglobulin Fc Fragments
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Interleukin-13
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Interleukin-13 Receptor alpha1 Subunit
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Receptors, Interleukin
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Receptors, Interleukin-13
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Receptors, Interleukin-4
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Recombinant Fusion Proteins
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Interleukin-4
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Ovalbumin