Abstract
Progression of malignant potential in ovarian cancer was investigated by comparing recurrent tumor with their primary tumor counterparts in terms of p53 and CD44 variant 6 (CD44v6) expression. Forty-three paired primary and recurrent tumors were immunohistochemically evaluated for expression of p53 and CD44v6. A paired analysis revealed that p53 and CD44v6 expression were significantly greater in recurrent tumors than those in the primary counterparts with statistical significance, respectively (P=0.0055 and 0.0071; Wilcoxon signed-rank test). No relationship between these two proteins was found. These results suggested that recurrent ovarian cancer may possibly express a stronger malignant potential in comparison to the primary tumor.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma, Clear Cell / chemistry
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Adenocarcinoma, Clear Cell / drug therapy
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Adenocarcinoma, Clear Cell / pathology
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Adenocarcinoma, Clear Cell / secondary
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Adenocarcinoma, Mucinous / chemistry
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Adenocarcinoma, Mucinous / drug therapy
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Adenocarcinoma, Mucinous / pathology
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Adenocarcinoma, Mucinous / secondary
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Carcinoma, Endometrioid / chemistry
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Carcinoma, Endometrioid / drug therapy
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Carcinoma, Endometrioid / pathology
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Carcinoma, Endometrioid / secondary
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Cisplatin / administration & dosage
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Cyclophosphamide / administration & dosage
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Cystadenocarcinoma, Papillary / chemistry
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Cystadenocarcinoma, Papillary / drug therapy
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Cystadenocarcinoma, Papillary / pathology
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Cystadenocarcinoma, Papillary / secondary
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Disease Progression
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Epirubicin / administration & dosage
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Female
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Genes, p53*
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Glycoproteins / analysis*
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Humans
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Hyaluronan Receptors / analysis*
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Middle Aged
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Neoplasm Metastasis
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Neoplasm Proteins / analysis*
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Ovarian Neoplasms / chemistry*
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Ovarian Neoplasms / drug therapy
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Ovarian Neoplasms / pathology
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Ovarian Neoplasms / secondary*
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Tumor Suppressor Protein p53 / analysis*
Substances
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CD44v6 antigen
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Glycoproteins
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Hyaluronan Receptors
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Neoplasm Proteins
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Tumor Suppressor Protein p53
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Epirubicin
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Cyclophosphamide
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Cisplatin