Chloroquine inhibits HIV-1 replication in human peripheral blood lymphocytes

W M Pardridge; J Yang; A Diagne

doi:10.1016/s0165-2478(98)00096-0

Chloroquine inhibits HIV-1 replication in human peripheral blood lymphocytes

Immunol Lett. 1998 Nov;64(1):45-7. doi: 10.1016/s0165-2478(98)00096-0.

Authors

W M Pardridge¹, J Yang, A Diagne

Affiliation

¹ Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1682, USA. [email protected]

PMID: 9865601
DOI: 10.1016/s0165-2478(98)00096-0

Abstract

Chloroquine has inhibitory effects on human immunodeficiency deficiency virus (HIV)-1 replication in human lymphocytes with an ED50 of 15 microM, which approximates the chloroquine plasma concentration generated in the acute treatment of malaria. Chloroquine has a parallel inhibitory effect on DNA replication in human lymphocytes, although the inhibitory effect on DNA replication is not as pronounced as is the drug inhibition of HIV-1 replication in the cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antimalarials / blood
Antimalarials / pharmacology
Cell Division / drug effects
Chloroquine / blood
Chloroquine / pharmacology*
DNA / biosynthesis
Dose-Response Relationship, Drug
HIV-1 / drug effects*
HIV-1 / physiology
Humans
Lymphocytes / drug effects
Lymphocytes / virology*
Time Factors
Virus Replication / drug effects*

Substances

Antimalarials
Chloroquine
DNA