Abstract
Novel isodideoxy nucleosides with exocyclic methylene were synthesized starting from L-xylose utilizing anomeric demethoxylation, Wittig reaction and Mitsunobu reaction as key steps and evaluated for antiviral activity.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyclovir / pharmacology
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Cell Survival / drug effects
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Cytomegalovirus / drug effects
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Dideoxynucleosides / chemical synthesis*
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Dideoxynucleosides / chemistry
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Dideoxynucleosides / pharmacology
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Drug Design
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Ganciclovir / pharmacology
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HIV-1 / drug effects
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Herpesvirus 1, Human / drug effects
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Herpesvirus 2, Human / drug effects
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Humans
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Hydrocarbons
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Indicators and Reagents
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Methane / analogs & derivatives*
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Microbial Sensitivity Tests
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Structure-Activity Relationship
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Xylose
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Zidovudine / pharmacology
Substances
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Antiviral Agents
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Dideoxynucleosides
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Hydrocarbons
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Indicators and Reagents
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carbene
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Zidovudine
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Xylose
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Methane
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Ganciclovir
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Acyclovir