Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere

Bioorg Med Chem Lett. 1998 Mar 17;8(6):687-90. doi: 10.1016/s0960-894x(98)00098-5.

Abstract

Design and synthesis of a series of very potent nonpeptide HIV protease inhibitors are described. The inhibitors are derived from novel high affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Line
  • Drug Design
  • HIV Protease Inhibitors / chemical synthesis*
  • Humans
  • Ligands
  • Models, Chemical
  • Saquinavir / analogs & derivatives
  • Saquinavir / chemistry
  • Sulfonamides / chemistry*

Substances

  • HIV Protease Inhibitors
  • Ligands
  • Sulfonamides
  • Saquinavir