Abstract
New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal activity (< or = 99.8%) against drug-resistant human breast cancer cells when co-administered with paclitaxel or doxorubicin. This activity is ascribed to the highly efficient blocking of P-glycoprotein efflux by these new taxanes.
Publication types
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
-
Animals
-
Dose-Response Relationship, Drug
-
Drug Resistance, Multiple*
-
Humans
-
Structure-Activity Relationship
-
Taxoids*
-
Triterpenes / chemistry*
-
Triterpenes / pharmacology
-
Tumor Cells, Cultured
Substances
-
ATP Binding Cassette Transporter, Subfamily B, Member 1
-
Taxoids
-
Triterpenes
-
10-deacetylbaccatine III