N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide: a novel antagonist at the 1A/2B NMDA receptor subtype

A P Tamiz; E R Whittemore; R M Schelkun; P W Yuen; R M Woodward; S X Cai; E Weber; J F Keana

doi:10.1016/s0960-894x(97)10215-3

N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide: a novel antagonist at the 1A/2B NMDA receptor subtype

Bioorg Med Chem Lett. 1998 Jan 20;8(2):199-200. doi: 10.1016/s0960-894x(97)10215-3.

Authors

A P Tamiz¹, E R Whittemore, R M Schelkun, P W Yuen, R M Woodward, S X Cai, E Weber, J F Keana

Affiliation

¹ Department of Chemistry, University of Oregon, Eugene 97403, USA.

PMID: 9871654
DOI: 10.1016/s0960-894x(97)10215-3

Abstract

A series of N-(2-phenethyl)cinnamides was synthesized and assayed for antagonism at three N-methyl-D-asparate (NMDA) receptor subtypes (NR1A/2A-C). N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide (6) was identified as a highly potent and selective antagonist of the NR1A/2B subtype.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cinnamates / chemistry
Cinnamates / pharmacology*
Excitatory Amino Acid Antagonists / chemistry
Excitatory Amino Acid Antagonists / pharmacology*
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*
Structure-Activity Relationship

Substances

Cinnamates
Excitatory Amino Acid Antagonists
N-(2-(hydroxyphenyl)ethyl)-4-chlorocinnamide
Receptors, N-Methyl-D-Aspartate