Abstract
Several thiazolidinediones having antioxidant moities in their structural motif have been synthesised and evaluated for their euglycemic and hypolipidemic activities. A few of them have been found to be superior to troglitazone.
MeSH terms
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Animals
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Antioxidants / chemical synthesis*
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Antioxidants / chemistry
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Antioxidants / pharmacology
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Blood Glucose / metabolism
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Diabetes Mellitus, Type 2 / blood
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Diabetes Mellitus, Type 2 / drug therapy
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Diabetes Mellitus, Type 2 / genetics
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Drug Design
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Hypoglycemic Agents / chemical synthesis*
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / pharmacology
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Hypolipidemic Agents / chemical synthesis*
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Hypolipidemic Agents / chemistry
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Hypolipidemic Agents / pharmacology
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Indicators and Reagents
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Mice
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Mice, Mutant Strains
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Structure-Activity Relationship
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Thiazoles / chemical synthesis*
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Thiazoles / chemistry
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Thiazoles / pharmacology
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Triglycerides / blood
Substances
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Antioxidants
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Blood Glucose
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Hypoglycemic Agents
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Hypolipidemic Agents
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Indicators and Reagents
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Thiazoles
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Triglycerides