Synthesis and antitumor activity of 4-phenyl-1-arylsulfonyl imidazolidinones

S H Jung; H S Lee; J S Song; H M Kim; S B Han; C W Lee; M Lee; D R Choi; J A Lee; Y H Chung; S J Yoon; E Y Moon; H S Hwang; S K Seong; D K Lee

doi:10.1016/s0960-894x(98)00261-3

Synthesis and antitumor activity of 4-phenyl-1-arylsulfonyl imidazolidinones

Bioorg Med Chem Lett. 1998 Jun 16;8(12):1547-50. doi: 10.1016/s0960-894x(98)00261-3.

Authors

S H Jung¹, H S Lee, J S Song, H M Kim, S B Han, C W Lee, M Lee, D R Choi, J A Lee, Y H Chung, S J Yoon, E Y Moon, H S Hwang, S K Seong, D K Lee

Affiliation

¹ College of Pharmacy, Chungnam National University, Taejon, Korea.

PMID: 9873387
DOI: 10.1016/s0960-894x(98)00261-3

Abstract

Novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolon es 3 synthesized show highly potent and broad cytotoxicities. Among them compound 3b (DW2143) exhibits much more potent cytotoxicities than doxorubicin and highly effective antitumor activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology*
Drug Screening Assays, Antitumor
Humans
Imidazoles / chemical synthesis*
Imidazoles / pharmacology*
Mice
Sulfones / chemical synthesis
Sulfones / pharmacology
Transplantation, Heterologous
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Imidazoles
Sulfones
DW 2143