Syntheses of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]-benzothiazolidine derivatives as a potential gastric H+/K(+)-ATPase inhibitor

S H Yoon; S Seo; Y Lee; S Hwang; D Y Kim

doi:10.1016/s0960-894x(98)00334-5

Syntheses of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]-benzothiazolidine derivatives as a potential gastric H+/K(+)-ATPase inhibitor

Bioorg Med Chem Lett. 1998 Jul 21;8(14):1909-12. doi: 10.1016/s0960-894x(98)00334-5.

Authors

S H Yoon¹, S Seo, Y Lee, S Hwang, D Y Kim

Affiliation

¹ Department of Applied Chemistry, Ajou University, Suwon, Korea.

PMID: 9873457
DOI: 10.1016/s0960-894x(98)00334-5

Abstract

A series of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]benzothiazolidine derivatives were synthesized and tested their inhibitory effects on gastric H+/K(+)-ATPase. Compound 4d exhibited potent in vitro inhibitory activity.

MeSH terms

Animals
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / pharmacology*
In Vitro Techniques
Proton Pump Inhibitors*
Rats
Stomach / enzymology*
Thiazoles / chemical synthesis*
Thiazoles / pharmacology*

Substances

Enzyme Inhibitors
Proton Pump Inhibitors
Thiazoles