Abstract
A series of the titled compounds was synthesized and tested for anti-Helicobacter pylori activities. We discovered Y-34867 having the most potent activity against Helicobacter pylori among the quinolones tested along with high photostability. Furthermore, Y-34867 showed an excellent therapeutic effect in the experimental Helicobacter pylori infected Mongolian gerbil model.
MeSH terms
-
4-Quinolones*
-
Animals
-
Anti-Infective Agents / chemical synthesis*
-
Anti-Infective Agents / chemistry
-
Anti-Infective Agents / pharmacology
-
Drug Stability
-
Fluoroquinolones*
-
Gerbillinae
-
Helicobacter Infections / drug therapy*
-
Helicobacter pylori / drug effects*
-
Indicators and Reagents
-
Microbial Sensitivity Tests
-
Molecular Structure
-
Naphthyridines / pharmacology
-
Ofloxacin / pharmacology
-
Quinolones / chemical synthesis*
-
Quinolones / chemistry*
-
Quinolones / pharmacology
-
Quinolones / therapeutic use
-
Solutions
-
Structure-Activity Relationship
-
Ultraviolet Rays
Substances
-
4-Quinolones
-
Anti-Infective Agents
-
Fluoroquinolones
-
Indicators and Reagents
-
Naphthyridines
-
Quinolones
-
Solutions
-
Y 26611
-
Ofloxacin
-
tosufloxacin
-
sparfloxacin