Abstract
We report that a systematic modification of an NK1 receptor selective antagonist resulted in the identification of novel compounds, 4c and 4d, with high affinity for both NK1 and NK2 receptors.
MeSH terms
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Amides / chemical synthesis*
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Amides / chemistry
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Amides / pharmacology
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Drug Design
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Humans
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Indicators and Reagents
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Kinetics
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Molecular Structure
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Neurokinin-1 Receptor Antagonists*
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Receptors, Neurokinin-2 / antagonists & inhibitors*
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Recombinant Proteins / antagonists & inhibitors
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Structure-Activity Relationship
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Tryptophan / analogs & derivatives
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Tryptophan / chemical synthesis*
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Tryptophan / chemistry
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Tryptophan / pharmacology
Substances
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Amides
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Indicators and Reagents
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Neurokinin-1 Receptor Antagonists
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Receptors, Neurokinin-2
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Recombinant Proteins
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Tryptophan