Abstract
A pool of RNA molecules that contained exclusively phosphorothioate internucleoside linkages was used as a starting point for the selection of aptamers that bind to basic fibroblast growth factor (bFGF), and appear to act as heparin mimics.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Base Sequence
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Binding Sites
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Cloning, Molecular
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DNA / chemistry*
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DNA Primers / chemistry
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Fibroblast Growth Factor 2 / genetics
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Fibroblast Growth Factor 2 / metabolism*
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Heparin / metabolism
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Humans
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Nucleic Acid Conformation*
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Oligodeoxyribonucleotides / chemical synthesis*
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Oligodeoxyribonucleotides / chemistry
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Oligodeoxyribonucleotides / metabolism
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RNA / chemical synthesis*
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RNA / chemistry
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RNA / metabolism
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Recombinant Proteins / metabolism
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Templates, Genetic
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Thionucleotides*
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Transcription, Genetic
Substances
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DNA Primers
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Oligodeoxyribonucleotides
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Recombinant Proteins
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Thionucleotides
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Fibroblast Growth Factor 2
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RNA
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Heparin
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DNA