Abstract
In this Letter, we describe the appearance of large, voltage-dependent currents in BLM induced by rigid rod-shaped polyols that function without charge and permanent dipole moment. The capacity of these symmetrical, nonpeptide models to form either short-living nanopores or small ion channels is shown to depend critically on the length of rigid-rod scaffold as well as the nature of the lateral side chains.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Chemical Phenomena
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Chemistry, Physical
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Electric Conductivity
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Ion Channel Gating / physiology
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Ion Channels / chemistry*
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Ion Channels / physiology*
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Lipid Bilayers / chemistry*
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Molecular Conformation
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Polymers / chemistry
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Sugar Alcohols / chemistry*
Substances
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Ion Channels
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Lipid Bilayers
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Polymers
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Sugar Alcohols