Abstract
A series of indole alkaloids of the aspidofractinine-type was assessed for their potential in reversing MDR in vincristine-resistant KB cells. Of the compounds tested, kopsiflorine, kopsamine, pleiocarpine, 11-methoxykopsilongine, lahadinine A and N-methoxycarbonyl-11,12-methylenedioxy-delta 16,17-kopsinine were found to show appreciable activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / pharmacology*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Drug Resistance, Multiple*
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Drug Resistance, Neoplasm
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Indoles / chemistry
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Indoles / pharmacology*
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Vincristine / pharmacology
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Indoles
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kopsinine F
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Vincristine