Rational design of a new series of mixed anti-HIV pronucleotides

N Schlienger; T Beltran; C Périgaud; I Lefebvre; A Pompon; A M Aubertin; G Gosselin; J L Imbach

doi:10.1016/S0960-894X(98)00535-6

Rational design of a new series of mixed anti-HIV pronucleotides

Bioorg Med Chem Lett. 1998 Nov 3;8(21):3003-6. doi: 10.1016/S0960-894X(98)00535-6.

Authors

N Schlienger¹, T Beltran, C Périgaud, I Lefebvre, A Pompon, A M Aubertin, G Gosselin, J L Imbach

Affiliation

¹ Laboratoire de Chimie Bioorganique, U.M.R. C.N.R.S. 5625, Université Montpellier II, France.

PMID: 9873664
DOI: 10.1016/S0960-894X(98)00535-6

Abstract

MonoSATE aryl phosphotriesters of AZT are able to deliver intracellularly the corresponding 5'-mononucleotide. This process requires activation by an esterase followed by a phosphodiesterase. This finding opens the way to the design of new pronucleotide series.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-HIV Agents / chemical synthesis*
Drug Design*
Humans
Nucleotides / chemical synthesis*
Prodrugs / chemical synthesis*
Zidovudine / analogs & derivatives*

Substances

Anti-HIV Agents
Nucleotides
Prodrugs
Zidovudine