DNA cleaving activities of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties

T Takahashi; H Tanaka; A Matsuda; T Doi; H Yamada; T Matsumoto; D Sasaki; Y Sugiura

doi:10.1016/s0960-894x(98)00606-4

DNA cleaving activities of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties

Bioorg Med Chem Lett. 1998 Dec 1;8(23):3303-6. doi: 10.1016/s0960-894x(98)00606-4.

Authors

T Takahashi¹, H Tanaka, A Matsuda, T Doi, H Yamada, T Matsumoto, D Sasaki, Y Sugiura

Affiliation

¹ Department of Chemical Engineering, Tokyo Institute of Technology, Japan.

PMID: 9873723
DOI: 10.1016/s0960-894x(98)00606-4

Abstract

The DNA cleaving properties of various enediyne analogues possessing sugar moieties and DNA-intercalators were investigated. The DNA cleaving experiments show that these hybrids analogues induced sequence-selective DNA cleavage and the simple sugars in the enediyne serve as a DNA recognition element for DNA cleavage.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibiotics, Antineoplastic / pharmacology*
Base Sequence
Carbohydrates
DNA / drug effects*
DNA / metabolism
Intercalating Agents / pharmacology*
Molecular Sequence Data
Structure-Activity Relationship

Substances

Antibiotics, Antineoplastic
Carbohydrates
Intercalating Agents
DNA