Abstract
A series of 5-hydroxy-4-quinolone (3) and 5-methoxy-4-quinolone (4) derivatives were synthesized as truncated acridone analogues and evaluated for antitumor, antiherpes and antituberculosis activities. Among them 5-hydroxy-8-methoxy-quinolone showed potent antitumor activity (IC50 = 17.7 microM for HL60) which was greater than that of acronycine. However, these compounds didn't show any significant antiherpes or antituberculosis activity.
MeSH terms
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Acridines / chemistry*
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Acridones
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Antiviral Agents / chemical synthesis
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Dioxanes / chemistry
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Drug Screening Assays, Antitumor
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Herpesvirus 1, Human / drug effects
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Herpesvirus 2, Human / drug effects
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects
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Quinolines / chemical synthesis*
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Quinolines / chemistry
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Quinolines / pharmacology*
Substances
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Acridines
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Acridones
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Antineoplastic Agents
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Antiviral Agents
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Dioxanes
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Quinolines
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acridone
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Meldrum's acid