Abstract
The structure activity relationship of flavonoids for anti-allergic actions was studied by determining the IC50 values for the degranulation. The hexosaminidase release from RBL-2H3 cells (degranulation marker) was employed as an estimate for the anti-allergic actions. Among 22 flavonoid compounds tested, luteolin, apigenin, diosmetin, fisetin, and quercetin were found to be most active with IC50 values less than 10 microM.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Allergic Agents / chemistry*
-
Anti-Allergic Agents / pharmacology
-
Catechin / pharmacology
-
Cell Line
-
Flavonoids / chemistry*
-
Flavonoids / pharmacology*
-
Flavonols
-
Isoflavones / pharmacology
-
Molecular Structure
-
Rats
-
Structure-Activity Relationship
-
beta-N-Acetylhexosaminidases / metabolism
Substances
-
Anti-Allergic Agents
-
Flavonoids
-
Flavonols
-
Isoflavones
-
Catechin
-
beta-N-Acetylhexosaminidases