Abstract
Using the novel lead from hydroxy acetyl substituted forskolin analogues, such as 7 beta-hydroxyacetyl-7 beta-deacetyl forskolin or 6 beta-hydroxyacetyl forskolin, a number of water soluble omega-amino acyl derivatives were synthesized. Two such compounds 6 and 18 showed better in vitro activity but failed to show in vivo activity.
MeSH terms
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Acetylation
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Animals
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Blood Pressure / drug effects*
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Cats
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Colforsin / analogs & derivatives*
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Colforsin / chemical synthesis*
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Colforsin / chemistry
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Colforsin / pharmacology
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Guinea Pigs
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Heart / drug effects
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Heart / physiology
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Heart Atria
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Hydroxylation
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In Vitro Techniques
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Indicators and Reagents
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Myocardial Contraction / drug effects*
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Myocardial Contraction / physiology
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Solubility
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Structure-Activity Relationship
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Water
Substances
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Indicators and Reagents
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Water
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Colforsin