Abstract
Bioactivity-directed fractionation led to the isolation of two new 7-dehydroaporphine alkaloids, 7-hydroxy-dehydrothalicsimidine (1) and 7-formyl-dehydrothalicsimidine (2), along with the five known alkaloids, thalicsimidine (3), norpurpureine (4), N-methyllaurotetanine (5), lirinidine (6) and N-methylasimilobine (7), from the leaves of Annona purpurea. Structural elucidation of these compounds was established by mass and spectroscopic analyses. Among them, 1, 3, 4, 6 and 7 exhibited significant inhibition of collagen, arachidonic acid and platelet activating factor-induced platelet aggregation; 1 also showed inhibition against thrombin-induced platelet aggregation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology*
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Aporphines / chemistry
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Aporphines / isolation & purification*
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Aporphines / pharmacology*
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Chemical Phenomena
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Chemistry, Physical
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Humans
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Platelet Activating Factor / pharmacology
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Platelet Aggregation / drug effects
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Platelet Aggregation Inhibitors / chemistry
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Platelet Aggregation Inhibitors / isolation & purification*
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Platelet Aggregation Inhibitors / pharmacology*
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Spectrophotometry
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Trees
Substances
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7-formyl-dehydrothalicsimidine
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7-hydroxy-dehydrothalicsimidine
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Alkaloids
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Aporphines
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Platelet Activating Factor
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Platelet Aggregation Inhibitors