Abstract
Certain tumor growth parameters (GP) of two mesenchymal transplantable tumors maintained on C57BL/6J mice were characterized. Considering that many experimental, clinical and epidemiologic data have indicated that n-3 and n-6 essential fatty acids are nutrients which may delay the development as well as improve the course of cancer, GPs were evaluated on hosts fed on a semisynthetic formula containing 5% of corn oil (CO) or cod liver oil (CLO) and stock diet (C group). Although survival and latency time of tumor-bearing mice were shortened, other GP as percentage of successful implants were improved by both oils in sarcoma-bearing hosts, suggesting that n-3 and n-6 fatty acids might play a modulating role for the development of these tumors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology
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Cell Division / drug effects
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Diet
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Dietary Fats, Unsaturated / pharmacology*
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Fatty Acids, Omega-3 / pharmacology*
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Fatty Acids, Omega-6
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Fatty Acids, Unsaturated / pharmacology*
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Female
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Fibrosarcoma / drug therapy
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Fibrosarcoma / pathology
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Fibrosarcoma / ultrastructure
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Lymphoma / drug therapy
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Lymphoma / pathology*
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Lymphoma / ultrastructure
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Male
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Mice
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Mice, Inbred C57BL
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Neoplasm Transplantation
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Sarcoma, Experimental / drug therapy
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Sarcoma, Experimental / pathology*
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Sarcoma, Experimental / ultrastructure
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Skin Neoplasms / drug therapy
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Skin Neoplasms / pathology*
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Skin Neoplasms / ultrastructure
Substances
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Antineoplastic Agents
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Dietary Fats, Unsaturated
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Fatty Acids, Omega-3
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Fatty Acids, Omega-6
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Fatty Acids, Unsaturated