Utility of PCR assay in diagnosis of en-plaque tuberculoma of the brain

J Clin Microbiol. 1999 Feb;37(2):467-70. doi: 10.1128/JCM.37.2.467-470.1999.

Abstract

This is the first report of a case in which diagnosis of en-plaque tuberculoma on the basis of magnetic resonance imaging (MRI) findings was confirmed by a Mycobacterium tuberculosis complex-specific PCR assay of cerebrospinal fluid. The accuracy of the diagnosis was supported by good response to antitubercular drugs, which was shown by repeat MRI studies performed after treatment.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antitubercular Agents / therapeutic use
  • Brain / pathology
  • Cerebrospinal Fluid / microbiology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Mycobacterium tuberculosis / genetics
  • Mycobacterium tuberculosis / isolation & purification*
  • Polymerase Chain Reaction*
  • Sensitivity and Specificity
  • Tuberculoma, Intracranial / diagnosis*
  • Tuberculoma, Intracranial / drug therapy
  • Tuberculoma, Intracranial / microbiology

Substances

  • Antitubercular Agents