Abstract
An extract from the entire Ixeris denticulata f. pinnatipartita plant afforded the guaianolide sesquiterpene lactone glucoside, 8 beta,15-dihydroxy-1(10),3,11(13)-guaiatrien-12,6-olide-15-O- glucopyranoside, along with the known flavonoids luteolin-7-O-glucoside and luteolin-7-O-glucuronide-6'-methyl ester; their structures were determined by spectroscopic methods. Ixerin Y inhibited the growth of human breast cancer MCF7 and MDA468 cell lines.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / toxicity
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Breast Neoplasms
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Cell Survival / drug effects
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Female
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Flavonoids / chemistry
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Flavonoids / isolation & purification
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Flavonoids / toxicity
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Glucosides / chemistry
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Glucosides / isolation & purification
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Humans
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Lactones / chemistry
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Lactones / isolation & purification
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Plant Leaves
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Plants, Medicinal*
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Flavonoids
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Glucosides
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Lactones
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Sesquiterpenes