We report a case of isolated myocardial involvement due to Aspergillus sp., in a patient with multiple organ failure but no demonstrable immune deficiency apart from corticosteroid therapy given for the three weeks prior to hospitalization. This patient died of septic shock 7 days after hospitalization. Aspergillus was isolated only once from a sputum specimen obtained 24 h before death. At post-mortem examination there are emboli and myocardial lesions containing clusters of hyphae as Aspergillus confirmed by indirect immunofluorescence. The other organs were free of fungi. This observation is remarkable because the cardiac involvement was isolated and no immunodeficiency was present.