[Hepatic clearance of 99mTc-GSA in cases of postoperative biliary atresia--a retrospective comparison with hepatic clearance of 99mTc-PMT]

Kaku Igaku. 1998 Nov;35(9):849-56.
[Article in Japanese]

Abstract

There are a few reports about usefulness of 99mTc-GSA liver scintigraphy (GSA imaging) for the evaluation of postoperative state of biliary atresia. However, comparison of significance for the disease between GSA imaging and 99mTc-PMT hepatobiliary imaging have not been reported. Fifty-six GSA imagings for 41 postoperative biliary atresia patients were reviewed and their scintigraphic findings and the functional parameters were compared with those obtained from 99mTc-PMT hepatobiliary imaging. In quantitative analysis, although the hepatic clearance of both tracers calculated by graphical analysis (Patlak plot) were well correlated in most cases, a discrepancy was observed in several cases with jaundice. The authors conclude that the hepatic clearance of 99mTc-GSA is a more accurate index of the hepatic reserve than that of 99mTc-PMT which can be influenced by hyperbilirubinemia and that the combination of both examinations is helpful to evaluate development of liver injury in postoperative biliary atresia patients.

Publication types

  • Comparative Study

MeSH terms

  • Biliary Atresia / diagnostic imaging*
  • Biliary Tract / diagnostic imaging
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Liver / diagnostic imaging*
  • Male
  • Organotechnetium Compounds*
  • Postoperative Period
  • Pyrrolidines*
  • Radionuclide Imaging
  • Radiopharmaceuticals*
  • Retrospective Studies
  • Technetium Tc 99m Aggregated Albumin*
  • Technetium Tc 99m Pentetate*
  • Tetracycline*

Substances

  • Organotechnetium Compounds
  • Pyrrolidines
  • Radiopharmaceuticals
  • Technetium Tc 99m Aggregated Albumin
  • technetium Tc 99m DTPA-galactosyl-human serum albumin
  • technetium Tc 99m pyrrolidino-methyltetracycline
  • Tetracycline
  • Technetium Tc 99m Pentetate