Abstract
The bactericidal activities of macrolides (clarithromycin, roxithromycin and azithromicyn) and lansoprazole, alone and in combination, against Helicobacter pylori strains were evaluated. It was found that the association of lansoprazole and clarithromycin resulted in a marked synergism, while the combination of roxithromycin or azithromycin with lansoprazole had synergistic and additive effects.
MeSH terms
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2-Pyridinylmethylsulfinylbenzimidazoles
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Anti-Bacterial Agents / pharmacology*
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Azithromycin / pharmacology
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Biopsy
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Clarithromycin / pharmacology
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Drug Synergism
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Helicobacter pylori / drug effects*
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Helicobacter pylori / isolation & purification
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Humans
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Kinetics
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Lansoprazole
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Microbial Sensitivity Tests / methods
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Omeprazole / analogs & derivatives*
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Omeprazole / pharmacology
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Roxithromycin / pharmacology
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Time Factors
Substances
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2-Pyridinylmethylsulfinylbenzimidazoles
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Anti-Bacterial Agents
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Lansoprazole
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Roxithromycin
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Azithromycin
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Clarithromycin
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Omeprazole