The structure of mithramycin reinvestigated

S E Wohlert; E Künzel; R Machinek; C Méndez; J A Salas; J Rohr

doi:10.1021/np980355k

The structure of mithramycin reinvestigated

J Nat Prod. 1999 Jan;62(1):119-21. doi: 10.1021/np980355k.

Authors

S E Wohlert¹, E Künzel, R Machinek, C Méndez, J A Salas, J Rohr

Affiliation

¹ Medical University of South Carolina, Department of Pharmaceutical Sciences, 171 Ashley Avenue, Charleston, South Carolina 29425-2303, USA.

PMID: 9917296
DOI: 10.1021/np980355k

Abstract

A reinvestigation of the structure of mithramycin, the principal product of Streptomyces argillaceus ATCC 12956, is reported. The structure elucidation was carried out with mithramycin decaacetate (4) using 2D NMR methods, including TOCSY, HMBC, and HSQC experiments. The work resulted in structure 3being confirmed for mithramycin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibiotics, Antineoplastic / chemistry*
Carbohydrate Sequence
Magnetic Resonance Spectroscopy
Molecular Sequence Data
Molecular Structure
Plicamycin / chemistry*

Substances

Antibiotics, Antineoplastic
Plicamycin