Mutations in 23S rRNA in Helicobacter pylori conferring resistance to erythromycin do not always confer resistance to clarithromycin

Antimicrob Agents Chemother. 1999 Feb;43(2):374-6. doi: 10.1128/AAC.43.2.374.

Abstract

Mutations conferring resistance to erythromycin or clarithromycin in Helicobacter pylori were studied. Mutation A2142G was consistently associated with clarithromycin MIC of > 256 micrograms/ml, whereas mutants carrying A2143G had MICs ranging from < or = 0.016 to > 256 micrograms/ml, suggesting that additional factors account for the observed multiple levels of resistance to clarithromycin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Clarithromycin / pharmacology*
  • Drug Resistance, Microbial / genetics
  • Erythromycin / pharmacology*
  • Helicobacter Infections / microbiology
  • Helicobacter pylori / drug effects*
  • Helicobacter pylori / genetics
  • Humans
  • Microbial Sensitivity Tests
  • Point Mutation*
  • RNA, Ribosomal, 23S / genetics*

Substances

  • Anti-Bacterial Agents
  • RNA, Ribosomal, 23S
  • Erythromycin
  • Clarithromycin