Abstract
Mutations conferring resistance to erythromycin or clarithromycin in Helicobacter pylori were studied. Mutation A2142G was consistently associated with clarithromycin MIC of > 256 micrograms/ml, whereas mutants carrying A2143G had MICs ranging from < or = 0.016 to > 256 micrograms/ml, suggesting that additional factors account for the observed multiple levels of resistance to clarithromycin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Clarithromycin / pharmacology*
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Drug Resistance, Microbial / genetics
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Erythromycin / pharmacology*
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Helicobacter Infections / microbiology
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Helicobacter pylori / drug effects*
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Helicobacter pylori / genetics
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Humans
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Microbial Sensitivity Tests
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Point Mutation*
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RNA, Ribosomal, 23S / genetics*
Substances
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Anti-Bacterial Agents
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RNA, Ribosomal, 23S
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Erythromycin
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Clarithromycin