Abstract
The activities of eight fluoroquinolones and linezolid, quinupristin-dalfopristin (Synercid), gentamicin, and vancomycin were tested against 96 ciprofloxacin-susceptible and 205 ciprofloxacin-resistant Staphylococcus aureus strains. Overall, clinafloxacin, followed by moxifloxacin and trovafloxacin, was the most active quinolone tested. For all isolates, linezolid and quinupristin-dalfopristin showed activities that were at least comparable to vancomycin, with no cross-resistance to any other test compound.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Anti-Infective Agents / pharmacology*
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Aza Compounds*
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Ciprofloxacin / pharmacology
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Drug Resistance, Microbial
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Fluoroquinolones*
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Gentamicins / pharmacology
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Humans
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Levofloxacin
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Microbial Sensitivity Tests
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Moxifloxacin
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Naphthyridines / pharmacology
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Ofloxacin / pharmacology
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Piperazines / pharmacology
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Quinolines*
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Quinolones / pharmacology
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / isolation & purification
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Vancomycin / pharmacology
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Virginiamycin / pharmacology
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Aza Compounds
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Fluoroquinolones
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Gentamicins
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Naphthyridines
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Piperazines
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Quinolines
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Quinolones
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Virginiamycin
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quinupristin-dalfopristin
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Ciprofloxacin
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Levofloxacin
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Vancomycin
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clinafloxacin
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trovafloxacin
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Ofloxacin
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grepafloxacin
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sparfloxacin
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Moxifloxacin